Uptake of extracellular double-stranded RNA by SID-2.

  title={Uptake of extracellular double-stranded RNA by SID-2.},
  author={Deborah L. McEwan and Alexandra S. Weisman and Craig P. Hunter},
  journal={Molecular cell},
  volume={47 5},
Ingested dsRNAs trigger RNA interference (RNAi) in many invertebrates, including the nematode Caenorhabditis elegans. Here we show that the C. elegans apical intestinal membrane protein SID-2 is required in C. elegans for the import of ingested dsRNA and that, when expressed in Drosophila S2 cells, SID-2 enables the uptake of dsRNAs. SID-2-dependent dsRNA transport requires an acidic extracellular environment and is selective for dsRNAs with at least 50 base pairs. Through structure-function… CONTINUE READING
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