Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages.

@article{Lesnik1992UptakeOE,
  title={Uptake of exogenous free cholesterol induces upregulation of tissue factor expression in human monocyte-derived macrophages.},
  author={Philippe Lesnik and Mustapha Rouis and Sonia Skarlatos and Howard S. Kruth and M. John Chapman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 21},
  pages={10370-4}
}
Lipid-laden macrophages present as foam cells may contribute to the hyperthrombotic state of human atherosclerotic lesions by the production of tissue factor (TF). We investigated the effect of exogenous nonlipoprotein cholesterol on the expression of TF by human monocyte-derived macrophages in culture. Nonlipoprotein cholesterol at 50 micrograms/ml increased TF activity 4-fold; TF induction was dose- and time-dependent. Expression of TF activity was positively correlated with the free… CONTINUE READING

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