Uptake of creatine phosphate into heart mitochondria: a leak in the creatine shuttle.

@article{Soboll1997UptakeOC,
  title={Uptake of creatine phosphate into heart mitochondria: a leak in the creatine shuttle.},
  author={Sibylle Soboll and Annette Conrad and A Eistert and Klaus Herick and Reinhard Prof Kraemer},
  journal={Biochimica et biophysica acta},
  year={1997},
  volume={1320 1},
  pages={
          27-33
        }
}
CrP uptake into isolated rat heart mitochondria was studied using silicone oil centrifugation. Further, the involvement of the mitochondrial adenine nucleotide translocase was examined by measuring CrP accumulation in mitochondria in the presence of substrates and inhibitors of the ATP/ADP-carrier and by investigating uptake kinetics in liposomes reconstituted with purified bovine heart adenine nucleotide translocase protein. CrP is accumulated in the matrix space of isolated rat heart… CONTINUE READING
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