Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells

@article{Pitas1985UptakeOC,
  title={Uptake of chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells},
  author={Robert E. Pitas and J K Boyles and Robert W. Mahley and Daniel M. Bissell},
  journal={The Journal of Cell Biology},
  year={1985},
  volume={100},
  pages={103 - 117}
}
Acetoacetylated (AcAc) and acetylated (Ac) low density lipoproteins (LDL) are rapidly cleared from the plasma (t1/2 approximately equal to 1 min). Because macrophages, Kupffer cells, and to a lesser extent, endothelial cells metabolize these modified lipoproteins in vitro, it was of interest to determine whether endothelial cells or macrophages could be responsible for the in vivo uptake of these lipoproteins. As previously reported, the liver is the predominant site of the uptake of AcAc LDL… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 43 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 41 references

In vivo and in vitro uptake and degradation of acetylated low density lipoprotein by rat liver endothelial, Kupffer, and parenchymal cells

  • J F.Nagelkerke., K. P. garto, T.J.C. van Berkel
  • J Biol. Chem
  • 1983

Similar Papers

Loading similar papers…