Uptake of cell-penetrating peptides is dependent on peptide-to-cell ratio rather than on peptide concentration.

  title={Uptake of cell-penetrating peptides is dependent on peptide-to-cell ratio rather than on peptide concentration.},
  author={M. H{\"a}llbrink and J. Oehlke and G. Papsdorf and M. Bienert},
  journal={Biochimica et biophysica acta},
  volume={1667 2},
  • M. Hällbrink, J. Oehlke, +1 author M. Bienert
  • Published 2004
  • Medicine, Chemistry
  • Biochimica et biophysica acta
  • The influence of the peptide-to-cell ratio and energy depletion on uptake and degradation of the cell-penetrating peptides (CPPs) MAP (model amphipathic peptide) was investigated. The intracellular concentration of the CPPs, MAP and penetratin was monitored while varying the number of cells at fixed peptide concentration and incubation volume, or changing the concentration and incubation volume at fixed cell number. The uptake of CPPs was shown to be dependent on the peptide/cell ratio. At… CONTINUE READING
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