Uptake of cell-penetrating peptides in yeasts.

  title={Uptake of cell-penetrating peptides in yeasts.},
  author={Tina Holm and Semharai Netzereab and Mats Hansen and U Lo Langel and Mattias H{\"a}llbrink},
  journal={FEBS letters},
  volume={579 23},
The uptake of different cell-penetrating peptides (CPPs) in two yeast species, Saccharomyces cerevisiae and Candida albicans, was studied using fluorescence HPLC-analyses of cell content. Comparison of the ability of penetratin, pVEC and (KFF)(3)K to traverse the yeast cell envelope shows that the cellular uptake of the peptides varies widely. Moreover, the intracellular degradation of the CPPs studied varies from complete stability to complete degradation. We show that intracellular… CONTINUE READING

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