Uptake of cationzied albumin coupled liposomes by cultured porcine brain microvessel endothelial cells and intact brain capillaries.

@article{Thle2002UptakeOC,
  title={Uptake of cationzied albumin coupled liposomes by cultured porcine brain microvessel endothelial cells and intact brain capillaries.},
  author={M Th{\"o}le and Stephanie Nobmann and Joerg Huwyler and Alexander Bartmann and Gert Fricker},
  journal={Journal of drug targeting},
  year={2002},
  volume={10 4},
  pages={337-44}
}
The suitability of protein-coupled liposomes as drug carriers for brain specific targeting was investigated using albumin (BSA) and cationized albumin (CBSA), respectively, as model proteins. Liposomes coated with polyethylene glycol (sterically stabilized, PEG-liposomes) were prepared from phosphatidylcholine, cholesterol, and a PEG-derivatized phospholipid and covalently coupled to thiolated BSA or CBSA. Liposomes were loaded with carboxy-fluorescein and rhodamine-labeled dipalmitoyl… CONTINUE READING
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