Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).

@article{Grube2006UptakeOC,
  title={Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5).},
  author={Markus Grube and Henriette Elisabeth Meyer zu Schwabedissen and Damaris Praeger and Jeanette Haney and K U M{\"o}ritz and Konrad Meissner and Dieter Rosskopf and Lothar Eckel and Michael B{\"o}hm and Gabriele Jedlitschky and Heyo Klaus Kroemer},
  journal={Circulation},
  year={2006},
  volume={113 8},
  pages={1114-22}
}
BACKGROUND To date, the uptake of drugs into the human heart by transport proteins is poorly understood. A candidate protein is the organic cation transporter novel type 2 (OCTN2) (SLC22A5), physiologically acting as a sodium-dependent transport protein for carnitine. We investigated expression and localization of OCTN2 in the human heart, uptake of drugs by OCTN2, and functional coupling of OCTN2 with the eliminating ATP-binding cassette (ABC) transporter ABCB1 (P-glycoprotein). METHODS AND… CONTINUE READING
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