Uptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure.

@article{Subramanian2016UptakeOA,
  title={Uptake of ascorbic acid by pancreatic acinar cells is negatively impacted by chronic alcohol exposure.},
  author={V. Sankara Subramanian and Padmanabhan Srinivasan and Hamid Said},
  journal={American journal of physiology. Cell physiology},
  year={2016},
  volume={311 1},
  pages={
          C129-35
        }
}
Vitamin C (ascorbic acid, AA) is indispensable for normal metabolism of all mammalian cells including pancreatic acinar cells (PACs). PACs obtain AA from their surroundings via transport across the cell membrane. Chronic alcohol exposure negatively affects body AA homeostasis; it also inhibits uptake of other micronutrients into PACs, but its effect on AA uptake is not clear. We examined this issue using both in vitro (266-6 cells) and in vivo (mice) models of chronic alcohol exposure. First… CONTINUE READING
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