Corpus ID: 38219606

Uptake of Tc-99m monophosphate complexes in bone and myocardial necrosis in animals.

@article{Kung1978UptakeOT,
  title={Uptake of Tc-99m monophosphate complexes in bone and myocardial necrosis in animals.},
  author={H. Kung and R. Ackerhalt and M. Blau},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={1978},
  volume={19 9},
  pages={
          1027-31
        }
}

H. Kung, R. Ackerhalt, M. Blau

Published 1978

Chemistry, Medicine

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

Bidentate monophosphates--phosphonoacetate (PAA), 2-phosphonoproprionate (PPA), 2-methyl-2-phosphonoproprionate (MPPA), and carbamyl phosphate (CAP)--which are pyrophosphate analogs, were successfully labeled with Sn(II)-reduced [99mTc] pertechnetate in high yield (greater than 95%). Biodistribution studies show that these Tc-99m-labeled monophosphates do localize in bone. At 2 hr after injection, Tc-99m CAP has average femur uptakes of 1.9% in rats and 2.9% in rabbits, which correspond to… CONTINUE READING

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