Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor

@article{Ezekowitz1991UptakeOP,
  title={Uptake of Pneumocystis carinii mediated by the macrophage mannose receptor},
  author={R. Alan B. Ezekowitz and D. J. L. Williams and Henry Koziel and Martine Y. K. Armstrong and A Warner and Frank F. Richards and Richard M. Rose},
  journal={Nature},
  year={1991},
  volume={351},
  pages={155-158}
}
HUMAN exposure to Pneumocystis carinii is common1,2 but, in the absence of acquired3 or genetic4 dysfunction of either cellular or humoral immunity, exposure rarely leads to illness. Although alveolar macrophages can degrade P. carinii5,6, macrophage receptors involved in P. carinii recognition have not been clearly defined. Characterization of a predominant surface glycoprotein of the high mannose type7,8 led us to investigate the role of the macrophage mannose receptor in this process. We… Expand
A Soluble Mannose Receptor Immunoadhesin Enhances Phagocytosis of Pneumocystis carinii by Human Polymorphonuclear Leukocytes In Vitro
TLDR
It is demonstrated that a recombinant soluble MR immunoadhesin, consisting of the essential carbohydrate binding MR ectodomain and the Fc‐region of human immunoglobulin (Ig)G1, binds P. carinii and leads to an 8.2‐fold increased uptake of P.carinii by phagocytic cells. Expand
Pneumocystis carinii enhances soluble mannose receptor production by macrophages.
TLDR
The results suggest that P. carinii organisms enhance the shedding of MR from the surface of alveolar macrophages, and that the resultant soluble MR binds to intra-alveolar organisms, thereby interfering with their non-opsonic uptake via the macrophage cell surface MR. Expand
Absence of the Macrophage Mannose Receptor in Mice Does Not Increase Susceptibility to Pneumocystis carinii Infection In Vivo
TLDR
Using a mouse model in which the mannose receptor has been deleted, it is found that the absence of this receptor is not sufficient to allow infection by P. carinii in otherwise immunocompetent mice. Expand
Pneumocystis carinii glycoprotein A binds macrophage mannose receptors
TLDR
It is demonstrated that gpA present on P. carinii interacts directly with mannose receptors, thereby mediating organism attachment to alveolar macrophages. Expand
Reduced binding and phagocytosis of Pneumocystis carinii by alveolar macrophages from persons infected with HIV-1 correlates with mannose receptor downregulation.
TLDR
It is suggested that HIV infection may alter innate immunity in the lungs, and that impaired alveolar macrophage mannose receptor-mediated binding and phagocytosis of P. carinii may contribute to the susceptibility of HIV-infected individuals to this opportunistic pulmonary pathogen. Expand
The role of alveolar macrophages in Pneumocystis carinii degradation and clearance from the lung.
Although studies indicate that alveolar macrophages participate in host defense against Pneumocystis carinii, their role in organism degradation and clearance from the lung has not yet beenExpand
Scavenger Receptor A Dampens Induction of Inflammation in Response to the Fungal Pathogen Pneumocystis carinii
TLDR
Alveolar macrophages from SRAKO mice had increased expression of CD11b on their surfaces, consistent with an activated phenotype, and data indicate that SRA controls inflammatory cytokines produced by alveolars in the context of P. carinii infection. Expand
Alveolar Macrophage–mediated Killing of Pneumocystis carinii f. sp. muris Involves Molecular Recognition by the Dectin-1 β-Glucan Receptor
TLDR
It is shown that nonopsonic phagocytosis and subsequent killing of P. carinii by alveolar macrophages is dependent upon recognition by the Dectin-1 β-glucan receptor. Expand
Mannosylated lipoarabinomannan interacts with phagocytes.
TLDR
It is demonstrated that this major carbohydrate antigen interacts selectively with murine phagocytes, i.e. granulocytes and macrophages, and may constitute one of the early factors of mycobacterial virulence. Expand
Pneumocystis carinii Does Not Induce Maturation of Human Dendritic Cells
TLDR
Investigation of the potential involvement of dendritic cells in the host response against P. carinii infection found them to play a central role in the regulation of specific immune responses. Expand
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