Uptake of CCR7 by KIR2DS4+ NK Cells Is Induced upon Recognition of Certain HLA-C Alleles

@inproceedings{Pesce2015UptakeOC,
  title={Uptake of CCR7 by KIR2DS4+ NK Cells Is Induced upon Recognition of Certain HLA-C Alleles},
  author={Silvia Pesce and Simona Carlomagno and Alessandro Moretta and Simona Sivori and Emanuela Marcenaro},
  booktitle={Journal of immunology research},
  year={2015}
}
The KIR2DS4 receptor is the oldest KIR2DS expressed by human NK lymphocytes. The specificity of recognition of this receptor for various HLA class I alleles has been demonstrated; however it remains poorly understood whether these interactions may result in the activation of some specific functions in NK cells. Here, we examined the functional outcome of the KIR2DS4/HLA class I interaction by the use of an alternative functional system based on the ability of KIR2DS4 to regulate the mechanism… CONTINUE READING