Uptake of 63Ni2+ in the central and peripheral nervous system of mice after oral administration: effects of treatments with halogenated 8-hydroxyquinolines.

@article{Borg1989UptakeO6,
  title={Uptake of 63Ni2+ in the central and peripheral nervous system of mice after oral administration: effects of treatments with halogenated 8-hydroxyquinolines.},
  author={Kathleen Borg and Hans Tj{\"a}lve},
  journal={Toxicology},
  year={1989},
  volume={54 1},
  pages={59-68}
}
Oral administration of 63Ni2+ to mice resulted in higher levels of the metal in the sciatic nerves, the trigeminal ganglia, spinal nerve roots and the spinal cord than in the cerebellum and the frontal cortex. In the sciatic nerves, the trigeminal ganglia and the spinal nerve roots a high vascular permeability may explain the preferential uptake of the 63Ni2+. The higher accumulation of the 63Ni2+ in the spinal cord than in the examined structures of the brain may be related to a diffusion from… CONTINUE READING