Uptake kinetics and receptor binding of glucocorticosteroids in head injury: an experimental study in a rat brain oedema model.


The uptake of dexamethasone (DM), as well as the glucocorticoid receptors binding sites (GCR) were studied in normal rat brain and in the rat brain after cold lesion of the right hemisphere. DM was taken up at a rate of 5.05 nmol/mg prot./min. by isolated cells of normal brain. This uptake was concentration (saturation at 10(-4) DM) and time dependent… (More)


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