Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression

@article{Randrup2004UptakeIO,
  title={Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression},
  author={Axel Abraham Randrup and Claus Br{\ae}strup},
  journal={Psychopharmacology},
  year={2004},
  volume={53},
  pages={309-314}
}
The dopamine theory of depression was studied by assessing the effect of antidepressant drugs on uptake of dopamine, noradrenaline, and serotonin in synaptosomes from rat brain. Five newer drugs—butriptyline, maprotiline, trimipramine, iprindole, and mianserine—exhibited rather potent inhibition of 3H-dopamine uptake in corpus striatum, as their IC50 values, which were in the order of 10-6–10-5 M, were only about 50 times higher than for nomifensine (IC50=10-7 M). The five drugs were weak… 
Reevaluation of the indoleamine hypothesis of depression. Evidence for a reduction of functional activity of central 5-HT systems by antidepressant drugs
TLDR
The therapeutic action of antidepressant drugs may in part be due to a reduced functional activity of some central 5-HT systems, and a new indoleamine hypothesis of depression is presented.
Interactions of amineptine with the neuronal dopamine uptake system: Neurochemicalin vitro andin vivo studies
TLDR
The data indicate that amineptine inhibits DA uptake and is virtually devoid of DA releasing effects, and displays a relatively low affinity for the NE uptake system.
Novel antidepressants and the biogenic amine hypothesis of depression. The case for iprindole and mianserin.
TLDR
The evidence is as yet insufficient to prove the superiority of iprindole over placebo in the treatment of those depressions characterized by endogenous symptoms, but the pharmacological profiles of these two drugs together with their clinical profiles are not inconsistent with the hypothesized role of biogenic amines in major depression.
Inhibitory potencies of trimipramine and its main metabolites at human monoamine and organic cation transporters
TLDR
Neither trimipramine nor its metabolites are highly potent inhibitors of the examined monoamine transporters, but at a steady state the sum of the concentrations of the parent compound and its active metabolites is almost two times higher than the plasma concentration of trimipramsine.
Antidepressants and ∝-adrenoceptors
TLDR
Some newer antidepressants neither inhibit monoamine oxidase (MAO) nor significantly affect monoamine uptake, while several highly effective uptake inhibitors appear not to be useful in the treatment of depression.
Effect of acute and chronic treatment of tandamine, a new heterocyclic antidepressant, on biogenic amine metabolism and related activities
TLDR
Tandamine affects biogenic amine mechanism following either acute or chronic administration in a fashion similar to desipramine, but unlike desipramsine, it exhibits relatively little anticholinergic properties, a further indication of the potential use of tandamine in the treatment of human depression, particularly where an increase in drive is desired.
Chapter 1. Antidepressants
TLDR
In an in vitro study, employing crude synaptosomal preparations from various rat brain regions, relevance of the Dopamine uptake in the mechanism of action of various antidepressants is examined and it is pointed out that it is difficult to ascribe the antidepressant effect to inhibit the uptake of a particular biogenic amine.
Biochemical hypotheses on antidepressant drugs: a guide for clinicians or a toy for pharmacologists?
TLDR
The development of knowledge about the mechanism of action of tricyclic and the so-called 'atypical' antidepressants (AD) is reviewed and an important role of dopamine in the activity of AD drugs is suggested by findings in the forced swimming test.
Chronic effects of clomipramine and clorgyline on regional levels of brain amines and acid metabolites in rats
TLDR
Clorgyline induced expected increases in amine levels and decreased acid metabolite levels in accord with previous studies, and CMI induced a decrease in 5-HIAA levels in all regions, although not as pronounced as the decrease observed with CLG.
Regulation of Dopamine Release in the Forebrain by Alpha2 Adrenoceptors and NMDA Glutamate Receptors
The dopaminergic system is involved in many behavioural and biological functions in the brain. The treatments for medical conditions such as schizophrenia, Parkinson’s disease, attention deficit
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 85 REFERENCES
Antidepressant drugs affect dopamine uptake.
TLDR
A number of widely used antidepressants inhibit dopamine uptake by rat brain nuclei-free homogenates, suggesting the existence of two components responsible for the accumulation of 3H-dopamine into synaptosomal suspensions from whole brain.
Effect of nomifensine (HOE 984), a new antidepressant, on uptake of noradrenaline and serotonin and on release of noradrenaline in rat brain synaptosomes.
TLDR
It is suggested that the centrally stimulating component of nomifensine is based upon its strong inhibition of catecholamine re-uptake into noradrenergic as well as dopaminergic nerve endings, which is lacking in most thymoleptic drugs.
Nomifensine: a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum
TLDR
Nomifensine is a new potent inhibitor of dopamine uptake into synaptosomes from rat brain corpus striatum and provides a useful tool for investigating the mechanistic aspects of synaptic events.
A comparison of the inhibitory activities of iprindole and imipramine on the uptake of 5-hydroxytryptamine and noradrenaline in brain slices.
TLDR
In spite of weak uptake inhibition, iprindole potentiated the awakening effect of 1-dopa in reserpinized mice and the inhibition of the neuronal uptake of the biogenic amines is discussed.
The effect of a tetracyclic antidepressant compound, Org GB94, on the turnover of biogenic amines in rat brain.
TLDR
It is concluded that Org GB94 increases the turnover of noradrenaline in the rat brain and in this respect differs qualitatively in its action from the tricyclic antidepressants.
Comparative pharmacological studies on butriptyline and some related standard tricyclic antidepressants.
TLDR
Butriptyline was a potent blocker of the arousal reaction induced by physostigmine and reduced rapid eye movement sleep with a conmitant increase in non-rapid eye movementSleep.
The contribution of drug research to investigating the nature of endogenous depression.
: A relationship between brain monamines and endogenous depression is suggested by observations on the mode of action of drugs producing or alleviating depressive symptoms. For example, reserpine is
The contribution of drug research to investigating the nature of endogenous depression.
  • A. Carlsson
  • Medicine
    Pharmakopsychiatrie, Neuro-Psychopharmakologie
  • 1976
TLDR
A causal relationship between disturbances in monoamine metabolism and depression is suggested, and 5-hydroxytryptamine is primarily involved in the control of mood, and noradrenaline in psychomotor activity.
Comparative study of the effects of mianserin, a tetracyclic antidepressant, and of imipramine on uptake and release of neurotransmitters in synaptosomes
TLDR
Results indicate that mianserin interferes in a way different from that of tricyclic antidepressants with the neurotransmitter transport mechanisms at the presynaptic level.
Some effects of a new tetracyclic anti-depressant compound, Org GB 94, on the metabolism of monoamines in the rat brain
  • B. Leonard
  • Chemistry, Medicine
    Psychopharmacologia
  • 2004
TLDR
It would appear that Org GB 94 is an antidepressant with a neurochemical profile unlike that of the tri-cyclic anti-depressants.
...
1
2
3
4
5
...