Uptake characteristics of pinocembrin and its effect on p-glycoprotein at the blood-brain barrier in in vitro cell experiments.

@article{Yang2012UptakeCO,
  title={Uptake characteristics of pinocembrin and its effect on p-glycoprotein at the blood-brain barrier in in vitro cell experiments.},
  author={Zhi-hong Yang and Xiao Sun and Yun Qi and Chao Mei and Xiao-Bo Sun and Guan-hua Du},
  journal={Journal of Asian natural products research},
  year={2012},
  volume={14 1},
  pages={14-21}
}
One purpose of the present study was to investigate the uptake characteristics of pinocembrin (PCB) and its effect on p-glycoprotein (P-gp) at the blood-brain barrier (BBB). Cultured rat brain microvascular endothelial cells (rBMECs) were used as an in vitro BBB model. Experiments were conducted to examine time-, concentration-, and temperature-dependent elements of PCB uptake, and the effect of classical P-gp inhibitors, cyclosporin A (CsA) and verapamil (Ver), on the steady-state uptake of… CONTINUE READING
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