Uptake and presentation of hepatitis C virus-like particles by human dendritic cells.

@article{Barth2005UptakeAP,
  title={Uptake and presentation of hepatitis C virus-like particles by human dendritic cells.},
  author={Heidi Barth and Axel Ulsenheimer and Gerd Rudolf Pape and Helmut Michael Diepolder and Marco Hoffmann and Christoph Neumann-Haefelin and Robert Thimme and Philipp Henneke and Reinhild Klein and Glaucia Paranhos-Baccala and Erik Depla and T Jake Liang and H. E. Blum and Thomas F Baumert},
  journal={Blood},
  year={2005},
  volume={105 9},
  pages={3605-14}
}
Hepatitis C virus (HCV) is a major cause of chronic hepatitis worldwide. Interaction of dendritic cells (DCs) with viral particles may play an important role in the immunopathogenesis of HCV infection. Since the synthesis or purification of infectious virions is limited, we used HCV-like particles (HCV-LPs) to study the interaction of HCV with human DCs. Immature DCs exhibited an envelope-specific and saturable binding of HCV-LPs, indicating receptor-mediated DC-HCV-LP interaction. Confocal… CONTINUE READING