Uptake and metabolism of estramustine in the Dunning R3327H tumour.

@article{Kruse1988UptakeAM,
  title={Uptake and metabolism of estramustine in the Dunning R3327H tumour.},
  author={Elisabeth Kruse and Beryl Hartley-Asp},
  journal={In vivo},
  year={1988},
  volume={2 6},
  pages={
          371-5
        }
}
A time-dependent plasma, tumour cell and nuclear uptake was found after intraperitoneal 3H-estramustine administration, in rats bearing the Dunning H tumour. Uptake of the drug into tumour cells had not reached a maximum after 4 h, whereas no real change was seen in the nuclear fraction after 2 h. Binding to the nuclear protein matrix of Dunning H tumour cells of 3H-estramustine was also found (2.46 pmol/g protein). High performance liquid chromatography demonstrated the existence of… CONTINUE READING