Uptake and metabolism of daunorubicin by human myelocytic cells


Daunorubicin uptake and metabolism were studied in vitro with human myeloid leukemia cell lines (KG1, ML1); erythroleukemia cell line (K562); and myeloblasts from two untreated patients with acute myelogenous leukemia (AML). Uptake of daunorubicin by all the above was very similar, but metabolism of daunorubicin to daunorubicinol and the levels of reductase… (More)
DOI: 10.1007/BF00257291


7 Figures and Tables

Slides referencing similar topics