Uptake and intracellular activity of moxifloxacin in human neutrophils and tissue-cultured epithelial cells.

@article{Pascual1999UptakeAI,
  title={Uptake and intracellular activity of moxifloxacin in human neutrophils and tissue-cultured epithelial cells.},
  author={{\'A}lvaro Pascual and Isabel Ruiz - Mall{\'e}n Pablo Dom{\'i}nguez Laura Calvet - Mir M Garc{\'i}a and Sof{\'i}a Ballesta and Evelio J. Perea},
  journal={Antimicrobial agents and chemotherapy},
  year={1999},
  volume={43 1},
  pages={12-5}
}
The penetration by moxifloxacin of human neutrophils (polymorphonuclear leukocytes [PMN]) and tissue-cultured epithelial cells (McCoy cells) was evaluated by a fluorometric assay. At extracellular concentrations of 5 mg/liter, the cellular-to-extracellular concentration ratios (C/E) of moxifloxacin in PMN and McCoy cells were 10.9 +/- 1.0 and 8.7 +/- 1.0, respectively (20 min; 37 degrees C). The uptake of moxifloxacin by PMN was rapid, reversible, nonsaturable (at extracellular concentrations… CONTINUE READING

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