Uptake and fate of surface modified silica nanoparticles in head and neck squamous cell carcinoma

  title={Uptake and fate of surface modified silica nanoparticles in head and neck squamous cell carcinoma},
  author={Emina Besic Gyenge and Xenia Darphin and Amina Wirth and Uwe Pieles and Heinrich Walt and Marius Gustav Bredell and Caroline Maake},
  booktitle={Journal of nanobiotechnology},
BACKGROUND Head and neck squamous cell carcinoma (HNSCC) is currently the eighth leading cause of cancer death worldwide. The often severe side effects, functional impairments and unfavorable cosmetic outcome of conventional therapies for HNSCC have prompted the quest for novel treatment strategies, including the evaluation of nanotechnology to improve e.g. drug delivery and cancer imaging. Although silica nanoparticles hold great promise for biomedical applications, they have not yet been… CONTINUE READING


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