Uptake and degradation of asialo-orosomucoid in hepatocytes from carcinogen-treated rats.

@article{Schwarze1985UptakeAD,
  title={Uptake and degradation of asialo-orosomucoid in hepatocytes from carcinogen-treated rats.},
  author={E. -W. Schwarze and Helge Tolleshaug and O Seglen},
  journal={Carcinogenesis},
  year={1985},
  volume={6 5},
  pages={777-82}
}
The function of the asialo-glycoprotein receptor was studied in hepatocytes from carcinogen-treated rats. The cells were isolated at an early stage of carcinogenesis, when histochemically demonstrable enzyme-altered foci but no neoplastic nodules could be observed. The rate of uptake of a trace concentration of [125I]asialo-orosomucoid in hepatocytes from carcinogen-treated rats was significantly below the rate in normal hepatocytes. In contrast, the rate of degradation of endocytosed protein… CONTINUE READING

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