Uptake and cytotoxicity of chitosan nanoparticles in human liver cells.

@article{Loh2010UptakeAC,
  title={Uptake and cytotoxicity of chitosan nanoparticles in human liver cells.},
  author={Jing Wen Loh and George C.T. Yeoh and Martin R. Saunders and Lee-Yong Lim},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={249 2},
  pages={
          148-57
        }
}
Despite extensive research into the biomedical and pharmaceutical applications of nanoparticles, and the liver being the main detoxifying organ in the human body, there are limited studies which delineate the hepatotoxicity of nanoparticles. This paper reports on the biological interactions between liver cells and chitosan nanoparticles, which have been widely recognised as biocompatible. Using the MTT assay, human liver cells were shown to tolerate up to 4h of exposure to 0.5% w/v of chitosan… CONTINUE READING

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