Uptake and binding of the serotonin 5-HT<ce:inf loc=post>1A</ce:inf> antagonist [<ce:sup loc=post>18</ce:sup>F]-MPPF in brain of rats: Effects of the novel P-glycoprotein inhibitor tariquidar

@article{Fougre2010UptakeAB,
  title={Uptake and binding of the serotonin 5-HT<ce:inf loc=post>1A</ce:inf> antagonist [<ce:sup loc=post>18</ce:sup>F]-MPPF in brain of rats: Effects of the novel P-glycoprotein inhibitor tariquidar},
  author={Christian la Foug{\`e}re and Guido B{\"o}ning and Hero Bartmann and Bj{\"o}rn W{\"a}ngler and Sebastian Nowak and Theresa Just and Erika Wagner and Petra Winter and Axel Rominger and Stefan F{\"o}rster and Franz-Josef Gildehaus and Pedro Rosa-Neto and Luciano Minuzzi and Peter Bartenstein and Heidrun Potschka and Paul Cumming},
  journal={NeuroImage},
  year={2010},
  volume={49},
  pages={1406-1415}
}
We used microPET to map the dose-response to the novel P-glycoprotein (P-gp) inhibitor tariquidar (TQD) of the initial influx of the P-gp substrate [(18)F]-MPPF in rat brain, and to test for effects of P-gp inhibition on the subsequent binding of [(18)F]-MPPF to serotonin 5-HT(1A) receptors. Summation maps of [(18)F]-MPPF uptake during the first 100 seconds after intravenous injection were calculated in groups of rats with vehicle (glucose 5%) pretreatment, or following pretreatment with TQD at… CONTINUE READING

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1406–1415 intracerebral activity in temporal lobe epilepsy: an [18F]MPPF–PET study

  • C. la Fougère
  • 2010

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