Uptake and Organ Distribution of Feed Introduced Plasmid DNA in Growing or Pregnant Rats

@inproceedings{Grnsberg2011UptakeAO,
  title={Uptake and Organ Distribution of Feed Introduced Plasmid DNA in Growing or Pregnant Rats},
  author={Idun Merete Gr{\o}nsberg and Lise Nordg{\aa}rd and Kristin A Fenton and Beate Hegge and Kaare M Nielsen and Susan Bardocz and {\'A}rp{\'a}d Pusztai and Terje Ingemar Traavik},
  year={2011}
}
Fragments of DNA present in food and feed are taken up by the gastrointestinal tract (GIT) of mammals. The extent of uptake varies according to organism, study design and DNA source. This study explores the hypothesis that actively growing, as well as pregnant rats, are more likely to take up DNA from the GIT than mature animals due to the high demand for nutrients for tissue and organ development. Plasmid DNA (pDNA) was added to standard feed for growing, and pregnant rats. The young rats… CONTINUE READING

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