Uptake, release, and metabolism of alanine in neurons and astrocytes in primary cultures.

@article{Westergaard1993UptakeRA,
  title={Uptake, release, and metabolism of alanine in neurons and astrocytes in primary cultures.},
  author={Niels J{\o}rgen Stenfeldt Westergaard and Thomas Varming and Ling Peng and Ursula Sonnewald and Leif Hertz and Arne Schousboe},
  journal={Journal of neuroscience research},
  year={1993},
  volume={35 5},
  pages={
          540-5
        }
}
The uptake, release, and metabolism of alanine were studied in primary cultures of cerebral cortical neurons or astrocytes and cerebellar granule neurons. All three cell types exhibited a saturable, sodium-dependent uptake of alanine with Km values (microM) of 256 +/- 30, 463 +/- 39, and 292 +/- 39, respectively, and Vmax values (nmol/min/mg) of 15.9 +/- 0.7, 7.9 +/- 0.01, and 17.4 +/- 0.8, respectively. The corresponding values (nmol/min/mg) for the specific activity of alanine… CONTINUE READING
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