Uptake, localization, and retention of gonadotropin-releasing hormone and gonadotropin-releasing hormone analogs in rat gonadotrophs.

@article{Duello1980UptakeLA,
  title={Uptake, localization, and retention of gonadotropin-releasing hormone and gonadotropin-releasing hormone analogs in rat gonadotrophs.},
  author={Theresa M. Duello and Terry M Nett},
  journal={Molecular and cellular endocrinology},
  year={1980},
  volume={19 1},
  pages={101-12}
}
Uptake and retention of GnRH by pituitary was compared to that of GnRH-ethylamide (GnRH-EA) and D-Ala6-GnRH-ethylamide (D-Ala6-GnRH-EA) to determine if differences in these parameters might partially account for the increased biopotency of these superactive analogs. Ovariectomized estrogen/progesterone-treated rats were given an intracarotid injection of either 125I-labeled GnRH, -GnRH-EA, or -D-Ala6-GnRH-EA. Maximum uptake occurred at 2 min for GnRH (8000 cpm/pit), 5 min for GnRH-EA (10 000… CONTINUE READING