Uptake, Impact, and Effectiveness of Rotavirus Vaccination in the United States: Review of the First 3 Years of Postlicensure Data

@article{Tate2011UptakeIA,
  title={Uptake, Impact, and Effectiveness of Rotavirus Vaccination in the United States: Review of the First 3 Years of Postlicensure Data},
  author={Jacqueline e. Tate and Margaret M Cortese and Daniel C. Payne and Aaron T. Curns and Catherine Yen and Douglas H. Esposito and Jennifer E. Cortes and Benjamin A. Lopman and Manish M Patel and Jon R. Gentsch and Umesh D. Parashar},
  journal={The Pediatric Infectious Disease Journal},
  year={2011},
  volume={30},
  pages={S56-S60}
}
Background: Rotavirus vaccine was recommended for routine use in US infants in 2006. Before the introduction of vaccine, rotavirus was the most common cause of severe gastroenteritis in children <5 years of age in the United States. Methods: We reviewed published data to summarize the US experience during the first 3 years of its rotavirus vaccination program. Results: Rotavirus seasons have been delayed and diminished in magnitude during the postvaccine era compared with the prevaccine era… 
A decade of experience with rotavirus vaccination in the United States – vaccine uptake, effectiveness, and impact
TLDR
The increasing use ofRotavirus vaccines has substantially diminished the burden and changed the epidemiology of rotavirus disease in U.S. children; efforts to increase rotav virus vaccine coverage should continue.
Lessons from the US rotavirus vaccination program.
TLDR
An unanticipated finding was that hospital admissions for diarrhea also declined among unvaccinated individuals aged 5 through 24 years, suggesting that the vaccine was having a herd effect, perhaps by preventing rotavirus transmission from a younger immunized cohort.
Effects of vaccine on rotavirus disease in the pediatric population
  • P. Dennehy
  • Medicine
    Current opinion in pediatrics
  • 2012
TLDR
Two well tolerated and effective rotav virus vaccines have reduced the health burden of rotavirus gastroenteritis in both developed and developing countries.
Effectiveness and impact of rotavirus vaccines in the United States – 2006–2012
TLDR
Substantial decreases in severe diarrheal disease in US children, exceeding the level expected based on vaccine coverage, as well as the extension of benefits to older age groups ineligible for vaccination have demonstrated both the direct and indirect impacts of vaccination in the USA.
Direct and indirect effects of rotavirus vaccination upon childhood hospitalizations in 3 US Counties, 2006-2009.
  • D. Payne, M. Staat, U. Parashar
  • Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2011
TLDR
Rotavirus vaccination has dramatically decreased rates of hospitalization for rotavirus infection among children in these US counties in 2008 and although rates among age groups eligible for vaccination remained low in 2009, indirect benefits disappeared.
Global Impact of Rotavirus Vaccination on Childhood Hospitalizations and Mortality From Diarrhea
TLDR
Implementation of rotavirus vaccines has substantially decreased hospitalizations from rotav virus and all-cause AGE during the first 10 years since vaccine licensure, including recent evidence from countries with high child mortality.
Assessing the impacts of the first year of rotavirus vaccination in the United Kingdom.
TLDR
In the first year after the introduction of universal vaccination against rotavirus, a profound reduction in gastroenteritis presentations and admissions was observed with a substantial possible herd effect seen in older children.
Direct, indirect, total, and overall effectiveness of the rotavirus vaccines for the prevention of gastroenteritis hospitalizations in privately insured US children, 2007-2010.
TLDR
It is demonstrated how direct, indirect, total, and overall effectiveness estimates and absolute benefits of rotavirus vaccines vary through the years following vaccine introduction, and how this could underestimate the sustained impact of the vaccine program.
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