Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1.

@article{Weber2006UpstreamSO,
  title={Upstream signaling of protein kinase C-epsilon in xenon-induced pharmacological preconditioning. Implication of mitochondrial adenosine triphosphate dependent potassium channels and phosphatidylinositol-dependent kinase-1.},
  author={N. Weber and O. Toma and H. Damla and J. I. Wolter and W. Schlack and B. Preckel},
  journal={European journal of pharmacology},
  year={2006},
  volume={539 1-2},
  pages={
          1-9
        }
}
  • N. Weber, O. Toma, +3 authors B. Preckel
  • Published 2006
  • Chemistry, Medicine
  • European journal of pharmacology
  • Xenon elicits preconditioning of the myocardium via protein kinase C-epsilon. We determined the implication of (1) the mitochondrial adenosinetriphosphate dependent potassium (K(ATP)) channels and (2) the 3'phosphatidylinositol-dependent kinase-1 (PDK-1) in activating protein kinase C-epsilon. For infarct size measurements, anaesthetized rats were subjected to 25 min of coronary artery occlusion followed by 120 min of reperfusion. Rats received xenon 70% during three 5-min periods before… CONTINUE READING
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