Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice.

@article{Bogdanovi1994UpstreamRE,
  title={Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice.},
  author={Zorica Bogdanovi{\'c} and Antonio Bedalov and Paul H Krebsbach and Dubravko Pavlin and C O Woody and Stephen H. Clark and Huw F Thomas and David W. Rowe and Barbara E. Kream and Alexander C. Lichtler},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1994},
  volume={9 2},
  pages={285-92}
}
The activity of fusion genes containing fragments of the COL1A1 promoter was measured in tissues from 6- to 8-day-old transgenic mice. ColCAT3.6 contains approximately 3.6 kb (-3521 to 115 bp) of the rat COL1A1 gene, the chloramphenicol acetyltransferase (CAT) reporter gene, and the SV40 splice and polyadenylation sequences. ColCAT2.3 and ColCAT1.7 are deletion constructs that contain 2296 and 1667 bp of COL1A1 upstream from the RNA start site, respectively. For each transgene, up to six lines… CONTINUE READING