Upstream regulatory elements in chick heme oxygenase-1 promoter: A study in primary cultures of chick embryo liver cells

@article{Lu2000UpstreamRE,
  title={Upstream regulatory elements in chick heme oxygenase-1 promoter: A study in primary cultures of chick embryo liver cells},
  author={Tian Huey Lu and Ying Shan and John M. Pepe and Richard W. Lambrecht and Herbert L. Bonkovsky},
  journal={Molecular and Cellular Biochemistry},
  year={2000},
  volume={209},
  pages={17-27}
}
Previously, chick heme oxygenase-1 (cHO-1) gene was cloned by us and two regions important for induction by sodium arsenite were identified. These two regions were found to contain consensus sequences of an AP-1 (-1580 to -1573) and a MRE/cMyc complex (-52 to -41). In the current study, the roles of these two elements in mediating the sodium arsenite or cobalt chloride dependent induction of cHO-1 were investigated further. DNA binding studies and site-directed mutagenesis studies indicated… CONTINUE READING