Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150

@article{Putlyaeva2014UpstreamOR,
  title={Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150},
  author={Lidia V. Putlyaeva and Anton Schwartz and Kirill V. Korneev and Marcela Covic and Leonid Uroshlev and V. Yu. Makeev and Sergey E Dmitriev and Dmitry V. Kuprash},
  journal={Biochemistry (Moscow)},
  year={2014},
  volume={79},
  pages={1405-1411}
}
More than 40% of human genes contain upstream open reading frames (uORF) in their 5′-untranslated regions (5′-UTRs) and at the same time express at least one truncated mRNA isoform containing no uORF. We studied translational regulation by four uORFs found in the 5′-UTR of full-length mRNA for SLAMF1, the gene encoding CD150 membrane protein. CD150 is a member of the CD2 superfamily, a costimulatory lymphocyte receptor, a receptor for measles virus, and a microbial sensor on macrophages. The… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 39 references

A perspective on mammalian upstream open reading frame function.

The international journal of biochemistry & cell biology • 2013
View 2 Excerpts

uORF mediated translational control in eukaryotes, in Encyclopedia of Systems

J. N. Vaughn, A. G. Arnim
eds.) Springer Science & Business Media, • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…