Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor alpha.

@article{Kos2002UpstreamOR,
  title={Upstream open reading frames regulate the translation of the multiple mRNA variants of the estrogen receptor alpha.},
  author={Martin Kos and Stefanie Denger and George Reid and Frank Gannon},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 40},
  pages={37131-8}
}
It is by now well established that the estrogen receptor alpha (ER alpha) is transcribed from multiple promoters. One direct consequence of multiple promoters is the generation of mRNA variants with different 5'-untranslated regions (5'-UTRs). However, the potential roles of these individual mRNA variants are not known. All 5'-UTRs of ER alpha contain between one and six upstream open reading frames. In this study the effect of the 5'-UTRs of major human and mouse ER alpha mRNA variants on… CONTINUE READING