Upstream and downstream of mTOR.

@article{Hay2004UpstreamAD,
  title={Upstream and downstream of mTOR.},
  author={N. Hay and N. Sonenberg},
  journal={Genes \& development},
  year={2004},
  volume={18 16},
  pages={
          1926-45
        }
}
The evolutionarily conserved checkpoint protein kinase, TOR (target of rapamycin), has emerged as a major effector of cell growth and proliferation via the regulation of protein synthesis. Work in the last decade clearly demonstrates that TOR controls protein synthesis through a stunning number of downstream targets. Some of the targets are phosphorylated directly by TOR, but many are phosphorylated indirectly. In this review, we summarize some recent developments in this fast-evolving field… Expand

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References

SHOWING 1-10 OF 217 REFERENCES
TOR Signaling
Regulation of cellular growth by the Drosophila target of rapamycin dTOR.
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin.
TOR signalling in bugs, brain and brawn
Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae
  • J. Crespo, M. Hall
  • Biology, Medicine
  • Microbiology and Molecular Biology Reviews
  • 2002
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
Rheb promotes cell growth as a component of the insulin/TOR signalling network
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
The Molecular Target of Rapamycin (mTOR) as a Therapeutic Target Against Cancer
...
1
2
3
4
5
...