Upstream ORFs Influence Translation Efficiency in the Parasite Trypanosoma cruzi

  title={Upstream ORFs Influence Translation Efficiency in the Parasite Trypanosoma cruzi},
  author={Santiago Rad{\'i}o and B. Garat and J. Sotelo-Silveira and Pablo Smircich},
  journal={Frontiers in Genetics},
  • Santiago Radío, B. Garat, +1 author Pablo Smircich
  • Published 2020
  • Biology, Medicine
  • Frontiers in Genetics
  • It is generally accepted that the presence of ORFs in the 5′ untranslated region of eukaryotic transcripts modulates the production of proteins by controlling the translation initiation rate of the main CDS. In trypanosomatid parasites, which almost exclusively depend on post-transcriptional mechanisms to regulate gene expression, translation has been identified as a key step. However, the mechanisms of control of translation are not fully understood. In the present work, we have annotated the… CONTINUE READING
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