Upstream ORFs Influence Translation Efficiency in the Parasite Trypanosoma cruzi

@article{Rado2020UpstreamOI,
  title={Upstream ORFs Influence Translation Efficiency in the Parasite Trypanosoma cruzi},
  author={Santiago Rad{\'i}o and B. Garat and J. Sotelo-Silveira and Pablo Smircich},
  journal={Frontiers in Genetics},
  year={2020},
  volume={11}
}
  • Santiago Radío, B. Garat, +1 author Pablo Smircich
  • Published 2020
  • Biology, Medicine
  • Frontiers in Genetics
  • It is generally accepted that the presence of ORFs in the 5′ untranslated region of eukaryotic transcripts modulates the production of proteins by controlling the translation initiation rate of the main CDS. In trypanosomatid parasites, which almost exclusively depend on post-transcriptional mechanisms to regulate gene expression, translation has been identified as a key step. However, the mechanisms of control of translation are not fully understood. In the present work, we have annotated the… CONTINUE READING
    1 Citations

    Figures, Tables, and Topics from this paper

    References

    SHOWING 1-10 OF 54 REFERENCES
    Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei
    • 81
    • Highly Influential
    Regulation of fungal gene expression via short open reading frames in the mRNA 5′untranslated region
    • 147
    Posttranscriptional Control of Gene Expression in Yeast
    • J. E. McCarthy
    • Biology, Medicine
    • Microbiology and Molecular Biology Reviews
    • 1998
    • 229
    • PDF
    The composition of upstream open reading frames (uORF) in four genes from Trypanosoma cruzi typical strains
    • 4
    The regulatory potential of upstream open reading frames in eukaryotic gene expression
    • K. Wethmar
    • Biology, Medicine
    • Wiley interdisciplinary reviews. RNA
    • 2014
    • 123
    Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
    • 86
    • Highly Influential
    • PDF