Upstream A-tracts increase bacterial promoter activity through interactions with the RNA polymerase a subunit ( A-tract DNA y DNA curvature y UP element )

Upstream A-tracts stimulate transcription from a variety of bacterial promoters, and this has been widely attributed to direct effects of the intrinsic curvature of A-tract-containing DNA. In this work we report experiments that suggest a different mechanism for the effects of upstream A-tracts on transcription. The similarity of A-tract-containing… CONTINUE READING