Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery.

@article{Asmild2003UpscalingAA,
  title={Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery.},
  author={Margit Asmild and Nicholas Oswald and Karen M Krzywkowski and S\oren Friis and Rasmus B Jacobsen and Dirk Reuter and Rafael Taboryski and Jonathan Kutchinsky and Ras K Vestergaard and Rikke Louise Schr\oder and Claus B. S\orensen and Morten L. Bech and Mads Gersdorff Korsgaard and Niels J Willumsen},
  journal={Receptors & channels},
  year={2003},
  volume={9 1},
  pages={49-58}
}
Effective screening of large compound libraries in ion channel drug discovery requires the development of new electrophysiological techniques with substantially increased throughputs compared to the conventional patch clamp technique. Sophion Bioscience is aiming to meet this challenge by developing two lines of automated patch clamp products, a traditional pipette-based system called Apatchi-1, and a silicon chip-based system QPatch. The degree of automation spans from semi-automation (Apatchi… CONTINUE READING

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