Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p

@article{Sesaki2006Ups1pAC,
  title={Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p},
  author={Hiromi Sesaki and C. D. R. Dunn and Miho Iijima and Kelly A. Shepard and Michael P. Yaffe and Carolyn E. Machamer and Robert E. Jensen},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={173},
  pages={651 - 658}
}
Mgm1p is a conserved dynamin-related GTPase required for fusion, morphology, inheritance, and the genome maintenance of mitochondria in Saccharomyces cerevisiae. Mgm1p undergoes unconventional processing to produce two functional isoforms by alternative topogenesis. Alternative topogenesis involves bifurcate sorting in the inner membrane and intramembrane proteolysis by the rhomboid protease Pcp1p. Here, we identify Ups1p, a novel mitochondrial protein required for the unique processing of… CONTINUE READING

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