Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog.

  title={Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog.},
  author={Yoriko Masuda and Satoshi Haramizu and Kasumi Oki and Koichiro Ohnuki and Tatsuo Watanabe and Susumu Yazawa and Teruo Kawada and Shuichi Hashizume and Tohru Fushiki},
  journal={Journal of applied physiology},
  volume={95 6},
Capsiate is a nonpungent capsaicin analog, a recently identified principle of the nonpungent red pepper cultivar CH-19 Sweet. In the present study, we report that 2-wk treatment of capsiate increased metabolic rate and promoted fat oxidation at rest, suggesting that capsiate may prevent obesity. To explain these effects, at least in part, we examined uncoupling proteins (UCPs) and thyroid hormones. UCPs and thyroid hormones play important roles in energy expenditure, the maintenance of body… 

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