Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis.

@article{Ramjaun2007UpregulationOT,
  title={Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis.},
  author={Antoine R. Ramjaun and Stephen Tomlinson and Ayad Eddaoudi and Julian Downward},
  journal={Oncogene},
  year={2007},
  volume={26 7},
  pages={970-81}
}
Transforming growth factor-beta (TGFbeta)-activated signalling pathways can lead to apoptosis, growth arrest or promotion of malignant behaviour, dependent on cellular context. The molecular mechanisms involved in TGFbeta-induced apoptosis remain controversial; although changes in gene expression are thought to be pivotal to the process, several different candidate apoptotic initiators and mediators have been proposed. Smad4, a critical component of the TGFbeta-induced transcriptional machinery… CONTINUE READING

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