Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.

@article{Chavez2012UpregulationOT,
  title={Upregulation of thrombospondin-1 expression by leptin in vascular smooth muscle cells via JAK2- and MAPK-dependent pathways.},
  author={Ronaldo J. Chavez and Rebecca M. Haney and Ren{\'e} H. Cuadra and Rituparna Ganguly and Ravi Kumar Adapala and Charles Kumar Thodeti and P. Venkat Raman},
  journal={American journal of physiology. Cell physiology},
  year={2012},
  volume={303 2},
  pages={
          C179-91
        }
}
Hyperleptinemia, characteristic of diabetes and a hallmark feature of human obesity, contributes to the increased risk of atherosclerotic complications. However, molecular mechanisms mediating leptin-induced atherogenesis and gene expression in vascular cells remain incompletely understood. Accumulating evidence documents a critical role of a potent antiangiogenic and proatherogenic matricellular protein, thrombospondin-1 (TSP-1), in atherosclerosis. Although previous studies reported elevated… CONTINUE READING

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