Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis.

@article{Bisson2012UpregulationOT,
  title={Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis.},
  author={Gregory P. Bisson and Carolina Mehaffy and Corey D Broeckling and Jessica E Prenni and Dalin Rifat and Desmond S. Lun and Marcos D Burgos and Drew Weissman and Petros C Karakousis and Karen M Dobos},
  journal={Journal of bacteriology},
  year={2012},
  volume={194 23},
  pages={
          6441-52
        }
}
Multidrug-resistant tuberculosis has emerged as a major threat to tuberculosis control. Phylogenetically related rifampin-resistant actinomycetes with mutations mapping to clinically dominant Mycobacterium tuberculosis mutations in the rpoB gene show upregulation of gene networks encoding secondary metabolites. We compared the expressed proteomes and metabolomes of two fully drug-susceptible clinical strains of M. tuberculosis (wild type) to those of their respective rifampin-resistant, rpoB… CONTINUE READING
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