Upregulation of the hyperpolarization-activated current increases pacemaker activity of the sinoatrial node and heart rate during pregnancy in mice.

@article{Khoury2013UpregulationOT,
  title={Upregulation of the hyperpolarization-activated current increases pacemaker activity of the sinoatrial node and heart rate during pregnancy in mice.},
  author={Nabil El Khoury and Sophie Mathieu and Laurine Marger and Jenna L Ross and Gracia El Gebeily and Nathalie Ethier and C{\'e}line Fiset},
  journal={Circulation},
  year={2013},
  volume={127 20},
  pages={2009-20}
}
BACKGROUND Pregnancy is associated with a faster heart rate (HR), which is a risk factor for arrhythmias. However, the underlying mechanisms for this increased HR are poorly understood. Therefore, this study was performed to gain mechanistic insight into the pregnancy-induced increase in HR. METHODS AND RESULTS Using surface ECG we observed that pregnant (P) mice have faster HR (531±14 beats per minute [bpm]) compared with nonpregnant (NP) mice (470±27 bpm; P<0.03). Results obtained with… CONTINUE READING