Upregulation of the expression of epidermal growth factor and its receptor in gingiva upon cyclosporin A treatment.

@article{Chin2006UpregulationOT,
  title={Upregulation of the expression of epidermal growth factor and its receptor in gingiva upon cyclosporin A treatment.},
  author={Yu-Tang Chin and Yen-Teen Chen and Hsiao-Pei Tu and E Shen and Cheng-Yang Chiang and C H Gau and Shin Nieh and E Fu},
  journal={Journal of periodontology},
  year={2006},
  volume={77 4},
  pages={647-56}
}
BACKGROUND To understand the roles of epidermal growth factor (EGF) and EGF receptor (EGF-R) in cyclosporin A (CsA)-induced gingival overgrowth, expression of EGF and EGF-R upon CsA treatment was examined in an oral epidermoid carcinoma cell line of humans (OECM-1) and in edentulous gingiva of rats. METHODS In vitro study: after CsA treatment, OECM-1 cells were harvested to evaluate their mRNA and protein expression of EGF and EGF-R with reverse transcriptase-polymerase chain reaction (RT-PCR… CONTINUE READING