Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection.

@article{West2008UpregulationOT,
  title={Upregulation of the TLR3 pathway by Kaposi's sarcoma-associated herpesvirus during primary infection.},
  author={John Arthur West and Blossom A Damania},
  journal={Journal of virology},
  year={2008},
  volume={82 11},
  pages={
          5440-9
        }
}
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with several different human malignancies, including Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. KSHV establishes lifelong latency in the host and modulates the host immune response. Innate immunity is critical for controlling de novo viral infection. Toll-like receptors (TLRs) are key components of the innate immune system, and they serve as pathogen recognition receptors that stimulate the host… CONTINUE READING

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