Upregulation of the Suppressors of Cytokine Signaling 1 and 3 Is Associated with Arrest of Phosphorylated-STAT1 Nuclear Importation and Reduced Innate Response in Denguevirus-Infected Macrophages

@inproceedings{EstradaJimnezTania2016UpregulationOT,
  title={Upregulation of the Suppressors of Cytokine Signaling 1 and 3 Is Associated with Arrest of Phosphorylated-STAT1 Nuclear Importation and Reduced Innate Response in Denguevirus-Infected Macrophages},
  author={Estrada-Jim{\'e}nezTania and Mill{\'a}n-P{\'e}rez Pe{\~n}aLourdes and Flores-MendozaLilian and Sede{\~n}o-MongeVirginia and Santos-L{\'o}pezGerardo and Rosas-MurrietaNora and Reyes-CarmonaSandra and Ter{\'a}n-CabanillasEli and Hern{\'a}ndezJesus and Herrera-CamachoIrma and Vallejo-RuizVer{\'o}nica and Reyes-LeyvaJulio},
  year={2016}
}
Abstract To clarify whether the suppressors of cytokine signaling (SOCS) are associated with denguevirus (DENV) evasion of the antiviral response, we analyzed the expression kinetics of SOCS1 and SOCS3 and of the antiviral genes MxA and OAS during DENV infection of U937 macrophages that were or not treated with interferon (IFN)-α. DENV infection produced a viral titer three times higher in untreated than in IFN-α-treated cells (p < 0.001 at 72 h postinfection [p.i.]). Partial inhibition of DENV… CONTINUE READING