Upregulation of spinal NMDA receptors mediates hydrogen sulfide-induced hyperalgesia.


Hydrogen sulfide (H2S) is an endogenous neurotransmitter that importantly regulates various physiological and pathological events including pain signal transduction. In this study, we investigated the role of spinal NMDA receptors in the nociception induced by intraplantar injection of NaHS, an H2S donor. Intraplantar injection of NaHS into hindpaw… (More)
DOI: 10.1016/j.jns.2016.02.058