Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes.

@article{Wu2007UpregulationOS,
  title={Upregulation of sodium-dependent vitamin C transporter 2 expression in adrenals increases norepinephrine production and aggravates hyperlipidemia in mice with streptozotocin-induced diabetes.},
  author={Ximei Wu and Takuma Iguchi and Junko Hirano and Isami Fujita and Hidenori Ueda and Norio Itoh and Keiichi Tanaka and Tsuyoshi Nakanishi},
  journal={Biochemical pharmacology},
  year={2007},
  volume={74 7},
  pages={1020-8}
}
The hyperglycemia and hyperoxidation that characterize diabetes lead to reduced vitamin C (L-ascorbic acid, AA) levels in diabetic humans and animals. We examined the possibility that diabetes-induced low plasma AA levels impair AA distribution to various tissues and that these changes are closely related to the development of diabetic complications. AA levels were markedly decreased in the plasma and increased in the adrenals of mice with streptozotocin (STZ)-induced diabetes. Consistently… CONTINUE READING

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