Upregulation of retinal vascular endothelial growth factor mRNAs in spontaneously diabetic rats without ophthalmoscopic retinopathy. A possible participation of advanced glycation end products in the development of the early phase of diabetic retinopathy.

@article{Shirao1998UpregulationOR,
  title={Upregulation of retinal vascular endothelial growth factor mRNAs in spontaneously diabetic rats without ophthalmoscopic retinopathy. A possible participation of advanced glycation end products in the development of the early phase of diabetic retinopathy.},
  author={Yutaka Shirao and Sho-ichi Yamagishi and Tomomi Higashide and Masato Kobayashi and Kenji Katsuno and A Iyobe and Hirohisa Harada and Fumihiko Sato and Hiroto Miyata and Hiroshi Asai and Akihisa Nishimura and Masayuki Takahira and T Souno and Yoshihiko Segawa and Kensaku Maeda and Kenji Shima and Atsuko Mizuno and Hiroshi Yamamoto and Kazuo Kawasaki},
  journal={Ophthalmic research},
  year={1998},
  volume={30 6},
  pages={333-9}
}
Vascular endothelial growth factor (VEGF) has recently been shown to be involved in the pathogenesis of proliferative diabetic retinopathy. However, its involvement in the development of the early phase of diabetic retinopathy is not fully understood. In this study we investigated the retinal VEGF mRNA level in spontaneously diabetic Otsuka Long-Evans Tokushima fatty (OLETF) rats, a model of non-insulin-dependent diabetes, without overt retinopathy, using quantitative reverse-transcription… CONTINUE READING

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