Upregulation of osteopontin in Schwann cells of the sciatic nerves of Lewis rats with experimental autoimmune neuritis.

@article{Ahn2004UpregulationOO,
  title={Upregulation of osteopontin in Schwann cells of the sciatic nerves of Lewis rats with experimental autoimmune neuritis.},
  author={Meejung Ahn and Yongduk Lee and Changjong Moon and Jae-kwang Jin and Yoh Matsumoto and Chang-sung Koh and Hyung-Min Kim and Taekyun Shin},
  journal={Neuroscience letters},
  year={2004},
  volume={372 1-2},
  pages={137-41}
}
We examined the expression of osteopontin (OPN) in the sciatic nerves of rats with experimental autoimmune neuritis (EAN), using immunohistochemistry and immunoblotting, to study its involvement in the pathogenesis of autoimmune peripheral nervous system diseases. Constitutive OPN expression was detected in some Schwann cells; expression was increased after immunization with adjuvant alone. At day 14 after induction of EAN, many Schwann cells had a granular pattern of immunoreactivity, whereas… CONTINUE READING

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